Genetic prion disease: opportunities for early therapeutic intervention with rigorous pre-symptomatic trials
نویسندگان
چکیده
منابع مشابه
Early hearing detection and intervention programs: opportunities for genetic services.
Congenital hearing loss is relatively frequent and has serious negative consequences if it is not diagnosed and treated during the first few months of life. Babies with hearing loss who are identified early and provided with appropriate intervention develop better language, cognitive, and social skills. As a result of improvements in screening equipment and procedures, newborn hearing screening...
متن کاملPrion degradation pathways: Potential for therapeutic intervention
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be developed, strategies aimed at stimulating the degradation of PrP(Sc) have shown efficacy in experimental models of prion disease. Here, we de...
متن کاملTherapeutic alternatives for symptomatic intracranial atherosclerotic disease.
n w a s a s y m p t o m a t i c o r s y m p t o m a t i c [ 8 ] .
متن کاملThe endocannabinoid nervous system: unique opportunities for therapeutic intervention.
The active principle in marijuana, Delta(9)-tetrahydrocannabinol (THC), has been shown to have wide therapeutic application for a number of important medical conditions, including pain, anxiety, glaucoma, nausea, emesis, muscle spasms, and wasting diseases. Delta(9)-THC binds to and activates two known cannabinoid receptors found in mammalian tissue, CB1 and CB2. The development of cannabinoid-...
متن کاملMacrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention?
The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Opinion on Investigational Drugs
سال: 2020
ISSN: 1354-3784,1744-7658
DOI: 10.1080/13543784.2020.1839048